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Many peo­ple liv­ing with long-term pain (also known as chron­ic or per­sis­tent pain) are wor­ried about using med­i­cines like anti­de­pres­sants. They might wor­ry that the doc­tor thinks it’s ‘all in my mind’. And they want to know how the med­ica­tion works and whether it is safe. Unan­swered con­cerns like these can stop peo­ple con­tin­u­ing with med­i­cines that may help to reduce pain. In this leaflet, spe­cial­ist in pain med­i­cine Dr Chris Wells explains more.

If you would like to know more about the sources of evi­dence con­sult­ed for this pub­li­ca­tion here.


Dr Chris Wells has a dis­tin­guished career in pain med­i­cine, serv­ing on the coun­cil of many sci­en­tif­ic soci­eties. He was pres­i­dent of the Euro­pean Pain Fed­er­a­tion EFIC until 2017. He is the author of three books and more than 150 articles.

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